Alex Bregman started at shortstop for the stars and stripes and Jose Altuve has been a regular for Venezuela.
USA took home the key victory with home runs from Adam Jones and Eric Hosmer lifting Team USA in the eighth inning to win 4-2.
Bregman was ready to make an impact after getting just one at-bat before Wednesday. The Astros starting third baseman picked up a single against King Felix and Tigers minor leaguer Arcenio Leon.
It was a familiar formula to the end the game for Team USA, Pat Neshek and Luke Gregerson took over the final two innings. Neshek, now a Phillie, struck out Altuve to end the eighth inning.
Luke Gregerson ended the game with a double play groundout by Victor Martinez.