The Astros' only run of the game came from George Springer in the first inning. Springer smacked a 1-0 fastball to right field for his 18th home run of the season.
The White Sox pulled in front in the third inning. J.B. Shuck opened the frame with a walk, and Tim Anderson doubled to center to put two runners in scoring position. A run scored on an Adam Eaton groundout, and Jose Abreu singled home a second run.
Astros starter Collin McHugh worked around traffic in the first, second, and fifth inning before being pulled sixth with two runners on.
A.J. Hinch was ejected in the seventh after Quintana appear to throw at Evan Gattis following Chris Devenski hitting Abreu. Alex Avila, Brett Lawrie, and Dioner Navarro combined to get two more runs on the board in the eighth inning with three singles.
The game ended with two runners on and A.J. Reed at the plate but Reed couldn't repeat his feat of two days in a row with a ninth inning home run.
The Astros only had three hits in the game and were 0-for-4 with runners in scoring position