Carlos Correa put the Astros in the lead in the first with a groundout, scoring George Springer who led off the game with a double. The A's Mark Canha tied the game in the bottom of the inning with a solo home run.
The Astros took the lead back after another lead-off double, this time it was Marwin Gonzalez and Jake Marisnick driving him home with a sacrifice fly.
The A's not the game at 2-2 as Brett Lawrie tripled in a run, but Mike Fiers buckled down and kept a second run from scoring.
Coco Crisp, all-time Astro killer, broke the game open with a base-loaded double in the sixth. Fiers would be lifted, Josh Fields, Joe Thatcher and Vincent Velazquez would be unable to stop the bleeding until Oakland had six cross the plate.
The Astros would counter with four in the top the seventh, highlighted by a Jonathan Villar moonshot and a Carlos Correa three-run home run.
Josh Phegley's two-run home run in the seventh off Velasquez would prove to be the difference in the game. The Astros would get three runs in the eighth, to bring the score with in one, but couldn't find that final run.
The Astros sent out Scott Kazmir against Sonny Gray in game two.