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Mike Fiers made his first major league complete game and first win as an Astro count. Fiers pitched the 11th no-hitter in Astros france history. Here are the previous no-hitter in Astros history:
| Date | Pitcher | Final score | Opponent | Catcher |
| 5/17/1963 | Don Nottebart | 4–1 | Philadelphia Phillies | John Bateman |
| 4/23/1964 | Ken Johnson | 0–1 | Cincinnati Reds | Jerry Grote |
| 6/18/1967 | Don Wilson (1) | 2–0 | Atlanta Braves | Dave Adlesh |
| 5/1/1969 | Don Wilson (2) | 4–0 | at Cincinnati Reds | Don Bryant |
| 7/9/1976 | Larry Dierker | 6–0 | Montreal Expos | Ed Herrmann |
| 4/7/1979 | Ken Forsch | 6–0 | Atlanta Braves | Alan Ashby (1) |
| 9/26/1981 | Nolan Ryan* | 5–0 | Los Angeles Dodgers | Alan Ashby (2) |
| 9/25/1986 | Mike Scott | 2–0 | San Francisco Giants | Alan Ashby (3) |
| 9/8/1993 | Darryl Kile | 7–1 | New York Mets | Scott Servais |
| 6/11/2003 | Roy Oswalt (1 IP) Peter Munro(2.2 IP) Kirk Saarloos(1.1 IP) Brad Lidge (2 IP) Octavio Dotel (1 IP) Billy Wagner£(1 IP) |
8–0 | at New York Yankees | Brad Ausmus |
| 8/21/2015 | Mike Fiers | 3–0 | Los Angeles Dodgers | Jason Castro |
It is the first no-hitter thrown by an Astros in Minute Maid Park, and the first complete game no hitter since Darryl Kile in 1993. It is the seventh time the Dodgers have been no-hit in their history, the previous game was June 8, 2012 -- six Mariners pitchers combined (Kevin Millwood, Charlie Furbush, Stephen Pryor, Lucas Luetge, Brandon League, and Tom Wilhelmsen) for a no hitter.
Fiers threw a career high 134 pitches to complete the no-hitter.