| Round |
Overall Selection # |
Player | Position | School |
| 4 | 131 | BJ Hyatt | RHP | SC Sumter (JC)- SC |
| 5 | 161 | Brandon Wikoff | SS | Univ. of IL |
| 6 | 191 | Enrique Hernandez | SS | Amer. Mil. Academy (HS) |
| 7 | 221 | Dallas Keuchel | LHP | Univ. of Arkansas |
| 8 | 251 | Brandt Walker | RHP | Stanford |
| 9 | 281 | Ben Orloff | SS | UC Irvine |
| 10 | 311 | Erik Castro | 3B | San Diego St. |
| 11 | 341 | David Williams | C | Crowder College |
| 12 | 371 | Geoffery Thomas | RHP | Stephenson HS (GA) |
| 13 | 401 | Jake Goebbert | OF | Northwestern Univ. |
| 14 | 431 | David Berner | LHP | San Jose St. |
| 15 | 461 | Ryan Humphrey | CF | St. Louis CC- Meramec |
| 16 | 491 | Ronald Sanchez | 1B | Manuela Toro (HS) |
| 17 | 521 | Justin Harper | RHP | OK. City U. |
| 18 | 551 | James McDonald | RHP | Boston College |
| 19 | 581 | Brian Kemp | CF | St. Johns |
| 20 | 611 | Julio Martinez | RF | Nova Southeastern U. |
| 21 | 641 | Barry Butera | 2B | Boston College |
| 22 | 671 | Mark Jones | RHP | Mainheim Township HS |
| 23 | 701 | Robert Donovan | RHP | Stetson Univ. |
| 24 | 731 | Mike Modica | LHP | George Mason Univ. |
| 25 | 761 | Nicholas Stanley | 1B | Fla. Sou. College |
| 26 | 791 | Matthew Watson | 1B | Pompano Beach HS (FL) |
| 27 | 821 | Aaron Bray | 3B | UNC Charlotte |
| 28 | 851 | Eric Anderson | RHP | Mountain Vista HS (CO) |
| 29 | 881 | Garen Wright | CF | Putnam City HS (OK) |
| 30 | 911 | Brandon Petite | RHP | Vauxhall HS |
HLP Update, 1:27 PM CDT: We've made twelve picks so far today. Five pitchers and three shortstops have been taken, which has spelt an early draft trend of left side of the infield players (3B/SS) and pitchers. Ten of the twelve players selected are post high school players.
HLP Update, 4:41 PM CDT: Day Two is but a memory.
- In total through 31 picks made, the Astros have selected: 1 Catcher, 3 First Basemen, 1 Second Baseman, 3 Third Basemen, 4 Shortstops, 6 Outfielders, and 13 Pitchers
- Twelve of the players were drafted out of high school, and nineteen were plucked from either a Junior College or a Four Year University/College
- Eighth Round pick Brandt Walker (Stanford) hails from Austin and was the only player with Texas ties drafted so far by the Astros
- Two players drafted were teammates at Boston College: Barry Butera and James McDonald
- Robert Donovan (RHP) is the second player drafted by the Astros in the past five seasons from Stetson University (Chris Johnson being the other)
Astros Fourth Round Selection, RHP BJ Hyatt